Fluorescence Tomographic Imaging

for functional and molecular imaging at organ level (~1-5 mm resolution, ~5-40 mm imaging depth)

Overview:

Fluorescence Tomography Imaging (FTI) has emerged as a highly sensitive molecular imaging technology capable of spatially resolving the concentration of targeted and activated fluorescent agents located deep in soft tissue in vivo. FTI employs low energy hazard-proof near-infrared (NIR) radiation to obtain quantitative images, thus making it a safe tool for diagnosis in human patients. FTI imaging has been proven an invaluable tool for small animal imaging, drug development/screening, and general pharmacokinetics study. FTI has great potential for clinical applications such as cancer detection and guidance of tumor resection.

The PI was among the early developers who laid out the ground work of fluorescence propagation in highly scattering media (such as biological tissues) and tomographic imaging. Our recently resumed interests include (1) development of a user friendly compact system for small animal imaging (with or without a matching medium), (2) integration with other imaging/therapeutic systems for providing molecular assessment/guidance, (3) exploration of improved algorithms for 3D tomographic reconstruction with a good balance among speed, accuracy and flexible boundary conditions, and (4) development of molecularly specific fluorescent contrast agents with strong emphasis on clinical translation. For more information on contrast agents, please go to: Structured Gold Nanoparticles.

Figure 1. Schematic of a fluorescence tomographic imaging system and a representative reconstructed image slice. (Click to enlarge and view detailed caption)



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