Airway Imaging

utilizing high speed and high resolution OCT imaging for the study of chronic obstructive pulmonary disorders


Obstructive lung diseases (OLD) present an array of diseases that are characterized by poor airflow such as asthma, bronchitis and chronic obstructive pulmonary diseases (COPD). The mechanism of these diseases is still not clearly understood, making it critical to study the changes in the tissue morphology leading to OLDs. It has recently come to light that airway smooth muscle may play a large part in COPDs.

With current technologies, airway smooth muscle is relatively difficult to differentiate and study in depth. OCT provides intrinsically depth dependent information that can help visualize fine airway structures. By using OCT we can investigate changes in tissue structure with which may help elucidate progression towards OLDs.

Ongoing work:

OCT is a real-time imaging technology that can investigate small airways in high speed and high resolution. Our lab is interested in using endoscopic OCT technology to study the mechanisms behind OLDs and COPDs. Our current goals include:

  1. Developing portable high speed endoscopic imaging platforms.
  2. Developing ultrathin high resolution OCT endoscopes for use in 800 nm and 1300 nm OCT systems.
  3. Quantifying fine structure thickness in peripheral small airways in vivo.

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